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DAR No 4: Linaclotide. Constella® in the symptomatic management of irritable bowel syndrome with constipation

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The indication was granted...so what?

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  • Although authorized for irritable bowel syndrome with constipation it offers only symptomatic relief.
  • In the best of cases, one in five patients can benefit from treatment.
  • On the other hand, one in five patients can suffer from diarrhea as a secondary effect which can last for more than 28 days in half the cases.
  • There are no available studies evaluating linaclotide versus other recommended comparators (laxatives and spasmolytics).


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