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DTB No 5. Dapagliflozin, Forxiga® in type Diabetes Mellitus

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Urinating glucose has its problems


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  • The hypoglycaemic action of dapagliflozin is the result of an increase in urinary glucose excretion (glycosuria).
  • Given its mechanism of action, the incidence of genital and urinary tract infections is increased.
  • Its efficacy is not better than sulphonylureas or metformin, and it has not been compared with gliptins.
  • There is uncertainty on its effects on the kidney function, mortality and cancer incidence.

 

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