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DAR No 5. Dronedarone (Multaq®) for non-permanent atrial fibrillation

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Lower efficacy than amiodarone and a questionable safety profile


  • Dronedarone is less effective than amiodarone in preventing recurrent episodes of atrial fibrillation.
  • Its safety profile is far from established. An increase in mortality in patients with heart failure and a warning of hepatic abnormalities have been published.
  • Although it does not produce thyroid disorders like amiodarone, on a whole it has not been shown to be more effective.
  • The potential for interactions is even more complex than amiodarone.
  • In addition to this data, the price of dronedarone is ten times higher than that of amiodarone.
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